Keep track of Closely (one)pentobarbital will minimize the extent or outcome of hydrocodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Warning when discontinuing CYP3A4 inducers which might be coadministered with hydrocodone; plasma concentrations of hydrocodone may perhaps boost and may end up in perhaps fatal respiratory depressionSerious - Use Alternative (one)hydrocodone, pentobarbital.
Contraindicated (one)pentobarbital will lessen the extent or outcome of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or result of ramelteon by influencing hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Not known.
Contraindicated (1)pentobarbital will decrease the extent or effect of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will reduce the level or effect of zolpidem by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unidentified.
pentobarbital will minimize the extent or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
Observe Intently (1)pentobarbital will lower the level or result of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Loss of, or lowered reaction to tofacitinib may manifest when coadministered with strong CYP3A4 inducers
pentobarbital will minimize the extent or outcome of pantoprazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
pentobarbital will decrease the level or influence of nateglinide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep track of.
pentobarbital will decrease the level or result of armodafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Mysterious.
Coadministration of zuranolone with other CNS depressants may raise read more impairment of psychomotor general performance or CNS depressant effects. If unavoidable, consider dose reduction. .
Drugs that need prior authorization. This restriction requires that certain scientific criteria be fulfilled previous to the acceptance of the prescription.
pentobarbital will reduce the extent or impact of meloxicam by affecting hepatic enzyme CYP2C9/ten metabolism. Minor/Significance Unknown.
pentobarbital will lessen the extent or impact of rolapitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Lengthy-term coadministration of powerful CYP3A4 inducers with rolapitant might drastically lower rolapitant efficacy.